I-fuse is a revolutionary one-time programmable (OTP) mechanism that offers a reliable, physically modeled programming process based on heat dissipation and electro-migration. Unlike traditional fuses that can create debris upon breaking, I-fuse ensures a seamless and compact integration by operating without additional mask steps or hidden layers, thereby offering foundry independence. Its robust programming is grounded in true electro-migration physics, ensuring both programmability and high data security, with a short programming time and high reliability even in harsh environments exceeding 150°C.